Solid Tumors

Background Information

Malignant tumors invade and destroy adjacent tissue. As they consist of the body’s own cells, they are better tolerated by the immune system than other invasive agents such as pathogens. Moreover, tumors actively suppress the immune system. A small group of cells within the tumor - the tumor stem cells - are resistant to chemotherapy and radiotherapy, and have the potential to seed secondary tumors (metastases). Tumor stem cells display a molecule on their surface called ABCB5. This molecule could potentially be used as a basis for immunotherapies.

There is an urgent need for new therapies for malignancies such as malignant melanoma and colorectal cancer as they are among the most frequent causes of death in industrialized countries. Recent therapeutic approaches aim to break the immune system’s tolerance towards tumor cells, thus leading to eradication of tumors by the immune system. However, this concept relies on the existence or induction of tumor-specific immune cells. By targeting ABCB5 on tumor stem cells – either directly by specific antibodies or indirectly by boostering or inducing a specific cellular immune response against it –  new therapeutic options might arise for patients not or poorly responding to available therapies.


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Clinical Trials

We are now also recruiting patients for further clinical studies in phase I/IIa with allogeneic ABCB5-positive (ABCB5+) mesenchymal stem cells for the following indications: chronic venous ulcers (CVU), diabetic foot ulcers (DFU) and peripheral arterial occlusive disease (PAOD). For more information click HERE.


Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.