Limbal Stem Cell Deficiency (LSCD)

Current Situation

Limbal stem cells (LSC) are responsible for the regenerative potential of the corneal epithelium (outer eye layer). Patients suffering from LSCD either lack a natural pool of LSCs or the LSC compartment is dysfunctional. Consequently, there is a loss of the limbal barrier function between the clear cornea and dull conjunctiva. This leads to conjunctivalization and vascularization of the corneal tissue, as well as chronic inflammation of corneal tissue and stromal scarring. Limbal stem cell deficiency (LSCD) is one of the major causes of corneal blindness worldwide.

 

Objective

To restore the LSC pool and to regenerate corneal tissue through differentiation of ABCB5+ limbal stem cells into corneal epithelium, thus demonstrating that targeted stem cell therapy could potentially improve or restore vision.

 

Procedure

Primary limbal stem cells can be isolated and expanded from donor corneas and ABCB5+ LSCs can be isolated from these cell cultures.

Therapeutic activity of skin-derived ABCB5+ human stem cells as well as ABCB5+ LSCs is currently being examined in disease models of LSCD.

Efficacy of human LSCs in patients with LSCD will be confirmed in clinical studies.

 

Partner

 

Video

The following link leads to a video about the Nature Article "ABCB5 is a limbal stem cell gene required for corneal development and repair".

 

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News
License

Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

Clinical Trial

Together with our subsidiary RHEACELL we are recruiting patients with the indication chronic venous ulcer (CVU) for the clinical trial in phase 1/2a. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.

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