Limbal Stem Cell Deficiency (LSCD)

Current Situation

Limbal stem cells (LSC) are responsible for the regenerative potential of the corneal epithelium (outer eye layer). Patients suffering from LSCD either lack a natural pool of LSCs or the LSC compartment is dysfunctional. Consequently, there is a loss of the limbal barrier function between the clear cornea and dull conjunctiva. This leads to conjunctivalization and vascularization, as well as chronic inflammation of corneal tissue and stromal scarring. Limbal stem cell deficiency (LSCD) is one of the major causes of corneal blindness worldwide.

 

Objective

To restore the LSC pool and to regenerate corneal tissue through differentiation of ABCB5+ limbal stem cells into corneal epithelium, thus demonstrating that application af ABCB5+ LSCs could potentially improve or restore vision.

 

Procedure

Primary limbal stem cells can be isolated and expanded from donor corneas and ABCB5+ LSCs can be isolated from these cell cultures. Therapeutic efficacy of ABCB5+ LSCs is currently being examined in disease models of LSC and will be confirmed in clinical studies.

 

Partner

 

Paper

The following link leads to the related Nature Article: Ksander et al. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. Jul 2 2014

 

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Clinical Trials

We are now also recruiting patients for further clinical studies in phase I/IIa with allogeneic ABCB5-positive (ABCB5+) mesenchymal stem cells for the following indications: chronic venous ulcers (CVU), diabetic foot ulcers (DFU) and peripheral arterial occlusive disease (PAOD). For more information click HERE.

License

Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.

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