Diabetic Foot Ulcer (DFU)

Current Situation

Diabetes mellitus is responsible for a variety of foot pathologies contributing to complications by ulceration and potential necessity of amputation. Multiple pathologies may be implicated from vascular complications in the form of macro- and microangiopathy up to peripheral neuropathy. The delayed wound healing in these patients seems to be particularly resulting from high plasma glucose concentrations. The high plasma glucose concentrations also offer a ripe breeding area for bacterial growth at the wound site, rendering the ulcer more prone to infection, which indeed increases the risk of amputation of the affected part.

 

Objective

The aim of the study is to treat diabetic neuropathic ulcer and ultimately prevent amputation using ABCB5+ mesenchymal stem cells (ABCB5+ MSCs) in stem cell based drug development.

 

Procedure

Previous studies in murine chronic wound models have already shown that ABCB5+ MSCs significantly improve wound healing potential by counteracting M1 macrophage-mediated permanent inflammation and thus facilitating macrophage polarization (M1 to M2 switch), considering that similar inflammatory mechanisms are pivotal to the pathophysiology of diabetic foot ulcers.

Furthermore, ongoing studies investigate the beneficial effects of ABCB5+ MSC in the truly delayed wound healing observed for diabetes type II.

 

Partner

 

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News
License

Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

Clinical Trial

Together with our subsidiary RHEACELL we are recruiting patients with the indication chronic venous ulcer (CVU) for the clinical trial in phase 1/2a. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.

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