Closed Researched Projects

Central Innovation Program of the Federal Ministry of Economics and Technology

Funding reference: EP 121049

 

Current situation

In pharmaceutical research, there is a need for cell cultures of the three tissue types: endoderm, ectoderm and mesoderm. They should be derived from a single non-immortalized and non-tumorigenic cell line and are used as physiological models for pharmacological and toxicological tests.

TICEBA GmbH has profound knowledge in and holds various patents for isolating and cultivating pluripotent stem cells from human skin. As part of an R&D project, the conditions required for differentiation of pluripotent mesenchymal stem cells taken from the skin into the endoderm, ectoderm and mesoderm of the cotyledon were established and validated. As a result, a tool for testing pharmacological drugs or substances is now available.

 

Objective

To develop a cell differentiation assay (endodermal, ectodermal and mesodermal) based on pluripotent mesenchymal stem cells for use as a physiological model for pharmacological and toxicological testing of potential drugs.

 

Procedure

Procedure In addition to defining and validating the various biological constituents of ABCB5+ cells under GMP conditions, mycoplasma and endotoxin components could also be determined and validated.

 

Conclusion

Through the Central Innovation Program, TICEBA GmbH was able to create a cell differentiation tool for the pharmaceutical industry.

 

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License

Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

Clinical Trial

Together with our subsidiary RHEACELL we are recruiting patients with the indication chronic venous ulcer (CVU) for the clinical trial in phase 1/2a. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.

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