Cirrhosis of the Liver

Current Situation

Chronic liver diseases almost always lead to Cirrhosis of the Liver, resulting in impaired tissue architecture and scarring. This leads to loss of function and liver failure during end-stage liver disease. The main causes are alcohol abuse, steatosis (fatty liver), infection and certain medications. It is possible to treat both the main cause of liver cirrhosis (avoidance of all liver-damaging agents) and the associated complications. The only treatment option for end-stage liver disease is usually a liver transplant. Preliminary experiments have shown that ABCB5+ cells can differentiate into functional liver cells. Thus, stem cell therapy with ABCB5+ mesenchymal skin stem cells represents a promising approach for the treatment of liver cirrhosis.



To determine the in vivo and in vitro effects of ABCB5+ mesenchymal stem cells from the skin.



Regeneration efficiency following acute liver injury will be examined in disease models.

Additionally, the necessary safety studies on the safety of treatment for systemic treatment (i.v. administration) with ABCB5+ cells in the liver region were successfully completed.





The following link leads to a video of the Hong Kong University about ABCB5+ stem cells against liver cancer: Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer »


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Clinical Trials

We are now also recruiting patients for further clinical studies in phase I/IIa with allogeneic ABCB5-positive (ABCB5+) mesenchymal stem cells for the following indications: chronic venous ulcers (CVU), diabetic foot ulcers (DFU) and peripheral arterial occlusive disease (PAOD). For more information click HERE.


Besides the authorization to manufacture a human medicinal product in accordance with § 13 (1) of the German Medicinal Products Act (AMG) for autologous mesenchymal stem cells, TICEBA is also authorized to manufacture a medicinal product for allogeneic mesenchymal as well as allogeneic limbal ABCB5 + stem cells following a recent extension. For more information click HERE.

The Story of Stem Cells

Review our category "The Story of Stem Cells" with the newest topic "Stem cells in wound healing" HERE.